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KMID : 0882420200950020119
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Korean Journal of Medicine
2020 Volume.95 No. 2 p.119 ~ p.123
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Azathioprine-Induced Non-Cirrhotic Portal Hypertension in a Patient with Crohn’s Disease
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Park Min-Kyu
Lee Jae-Kwang
Kim Hyun-Soo
Chung Yun-Jin
Park Chang-Keun
Jung Jae-Kwon
Kim Dae-Jin
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Abstract
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Thiopurine-based drugs such as azathioprine and 6-MP are among the most common immunosuppressants used to treat inflammatory bowel disease, autoimmune hepatitis, various autoimmune diseases, and patients undergoing organ transplantation. The drugs are associated with various complications, of which one of the most serious is hepatotoxicity that may trigger non-cirrhotic portal hypertension. We report a case with this side-effect in a patient taking azathioprine to treat Crohn’s disease.
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KEYWORD
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Azathioprine, Hypertension, Portal, Nodular regenerative hyperplasia
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